Researchers hope to launch human clinical trials in their quest for a vaccine to prevent the buildup of pathological tau after demonstrating that this vaccine generated a robust immune response in ...

We investigated the temporal distribution of the p53-immunoreactive protein in conjunction with cellular damage and the expression of the p53 mRNA after focal cerebral ischemia in rats. Male Wistar ...

This external QC program comes free of charge to participating laboratories. The CSF biomarkers tau and amyloid ß (Aß) show promise as tools in the diagnostic work-up patients with suspected Alzheimer ...

CD47 is found to play a pivotal role in this immunosuppression by inducing the production of amyloid-β (Aβ), which interacts with ... B-cell numbers in CLP mice (Appendix Fig. S20). The mRNA levels of ...

Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new ...

Copyright: © 2025 Published by Elsevier Ltd. After outlining the various cases of supposed fraudulent research, Piller alleges—really without a logical link—that ...

Background: The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights ...

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, U.K. Centre for Respiratory Biology, Division of Medicine, University College London ...

To boost those proteins, they’ve created experimental versions of a genetic “tail” that attaches to so-called mRNA molecules that churn out the proteins. A report on the researchers’ proof-of-concept ...