CytoDyn has received FDA clearance to initiate a Phase II study of leronlimab in patients with relapsed or refractory micro-satellite stable colorectal cancer (CRC) (NCT06699835). The drug ...

The LifeTracDx ® test is based on analyzing two biomarkers: (1) circulating tumor cells (CTCs) and (2) Cancer Associated Macrophage-Like (CAML) cells, which are macrophages that engulf tumor cells.

This study aims to analyze publications on bevacizumab and CRC to explore and identify the trends and frontiers of this field. Methods: We collected 4,164 articles on bevacizumab and CRC from the Web ...

A study (85) identified two distinct functional states of macrophages in CRC: C1QC+ and SPP1+ macrophages. Specifically, C1QC+ macrophages exhibit phagocytic activity and antigen presentation ...

Macrophages, a type of white blood cell, adjust their molecular signaling patterns immediately after an infection, the researchers found. This short-term memory changes how macrophages respond to ...

(A) Volcano plot of DEGs in monocytes/macrophages between NC and CRC samples in the GSE164552 dataset. (B) Venn diagrams of common DEGs up- or down-regulated across the six scRNA-seq datasets (NC vs.

(A) Volcano plot of DEGs in monocytes/macrophages between NC and CRC samples in the GSE164552 dataset. (B) Venn diagrams of common DEGs up- or down-regulated across the six scRNA-seq datasets (NC vs.

Interestingly, this study noted an increase in the proportion of M1 macrophages and a decrease in M2 macrophages in CRC, contradicting the M1/M2 polarization theory. Functional analyses suggests that ...