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Controlling conformational changes in protein aromatic side chains Date: March 5, 2025 Source: Institute of Science Tokyo Summary: A novel protein cage system can control and visualize ...

MD-simulations reveal low- to high-affinity conformational shift of orthosteric site in the nicotinic acetylcholine receptor, offering insight into agonist roles in activation dynamics, and ...

CryoEM reconstructions support conformational heterogeneity in the PHTH–PRR region wherein the globular PHTH domain adopts a range of states arrayed around the autoinhibited SH3–SH2–kinase core.

Physicists are investigating if nuclear isomers could build the world’s most accurate clock or support the next generation of batteries.

Nuclear isomers are rare versions of elements with properties that mystified physicists when first discovered. Isomers are now used in medicine and astronomy, and researchers are set to discover ...

The studies reviewed here reveal the conformational dynamics underpinning the nucleotide selection, proofreading and 5′ nuclease activities of Pol I. Moreover, the mechanisms revealed for Pol I are ...

Both UX2 and UZ can then beta decay to form UII (uranium-234). The two states of protactinium proved that isomers exist. Since the first nuclear isomer was discovered in 1921 – exactly a century ago – ...

This article talks about using proton NMR spectroscopy for the identification o the isomers of ethyl acetate, butyric acid and isobutyric acid.