Quaid was previously married to actress P.J. Soles from 1978 to 1983. He then tied the knot with Meg Ryan in 1991. The exes welcomed son Jack, 33, before splitting in 2001. In 2004, Quaid married real estate broker Kimberly Buffington. They welcomed twins Thomas and Zoe, 17, in 2007. The pair divorced in 2018.

Dennis Quaid is revealing that the closest relationship he's ever had is with his wife, who is 39 years his junior. The A Dog's Purpose star, 71, recently gushed about the close relationship he shares with his wife,