To determine the ability of PTD-DRBD fusion proteins to deliver siRNAs, we generated a human H1299 lung adenocarcinoma reporter cell line using destabilized green fluorescent protein (dGFP) and ...

Figure 1: Targeting peptide expressed with Lamp2b is expressed on the external surface of exosomes. Figure 3: In vivo delivery of siRNA with targeted exosomes results in brain-specific gene knockdown.

To make the technique work in cultured mammalian cells, researchers must deliver small interfering RNAs (siRNAs), which are dsRNAs of 21-25 nucleotides, to the cell. They can use a wide range of ...

In contrast to miRNAs, siRNAs are usually perfectly complementary to their targets. They are thus very effective at eliminating gene expression. For this reason, synthetic siRNAs have been generated ...

A novel study reveals that targeting a single protein’s aggregation can dramatically reduce brain injury after stroke, potentially transforming how acute ischemic strokes are treated. Study: ...