The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

TAIPEI, May 16, 2025 /PRNewswire/ -- The broad-spectrum antiviral siRNA drug SNS812, co-developed by Oneness Biotech (4743.TW) and Microbio (Shanghai), has been selected for oral presentation at the ...

AbbVie has signed a collaboration and licensing agreement with US-based ADARx Pharmaceuticals, committing $335m upfront to access its small interfering RNA (siRNA) platform. The partnership gives ...

AbbVie is paying ADARx Pharmaceuticals $335 million upfront to secure options on next-gen small interfering RNA (siRNA) therapeutics across several disease areas. The collaboration and license ...

siRNA-AGO2 complex inhibits bacterial gene translation: a novel therapeutic strategy for superbug infection Peer-Reviewed Publication Nanjing University School of Life Sciences ...

Two start-ups have launched to develop next-generation drugs using small interfering RNA (siRNA) to silence genes. The first, Judo Bio, is a spin-off of the venture capital firm Atlas Venture. The ...

NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP. Journal of Controlled Release, 2024; 373: 738 DOI: 10.1016/j.jconrel.2024.07.055 ...

However, siRNA's therapeutic potential is limited by off-target effects, which occur when the siRNAs interact with non-target mRNA strands.

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases. However, siRNA drugs have challenges because siRNAs often ...

After this, 50 pmoL of Silencer™ Cy™3-labeled GAPDH siRNA against human/mouse/rat sequences (Thermo Fisher Scientific, United Kingdom) were added to the samples and incubated 20 min to form ...

Lab data in cells has shown that siRNA has the potential to treat COVID-19 infection better than existing antivirals, according to new research from UNSW's Kirby and RNA Institutes, published ...

(C) Western blot was conducted to evaluate the protein level of Beclin-1, Atg7 and GAPDH in HK-2 cell lysates. (D, E) Scatter plots showing the densitometry analysis of Beclin-1 and Atg7 normalized by ...