The nitric oxide-independent soluble guanylate cyclase activator ataciguat continued to show promise for slowing the progression of fibrocalcific aortic valve stenosis in phase I and II studies.

Safety of use during pregnancy or breastfeeding is uncertain. These drugs also act to increase intestinal fluid and intestinal movement by targeting receptors called guanylate cyclase-C (GC-C) ...

Adempas (riociguat) is the only drug in its class of soluble guanylate cyclase (sGC) stimulators. The drug is FDA-approved to treat PAH, more specifically, to improve tolerance for activity, reduce ...

Background: Guanylate-binding protein 1 (GBP1) is involved in the malignant progression of lung adenocarcinoma, particularly in the acquisition of invasive potential. However, its role in tumor ...

Here we report that isoamyl alcohol (IAA) induces bi-directional currents through a Gα- guanylate cyclase (GC)- cGMP signaling pathway in Caenorhabditis elegans olfactory neuron amphid wing “C” cell ...

Stressful experiences potently activate kappa opioid receptors (κORs). κORs in the ventral tegmental area regulate multiple aspects of dopaminergic and non-dopaminergic cell function. Here we show ...