Two novel agents targeting angiopoietin-like protein 3 demonstrated safety and lipid-lowering capabilities in phase 2 trials, ...

Obesity and related metabolic disorders, such as hyperlipidemia and non-alcoholic fatty liver disease, have become ...

Sep. 19, 2024 — A research team has discovered a mechanism in which blood stem cells respond to acute, severe anemia, through lipoprotein metabolism modification. It has been known how immediate ...

Credit: Getty Images Researchers conducted an exploratory analysis to evaluate outcomes associated with GLP-1RA use in type 2 diabetes with comorbid atrial fibrillation. GLP-1RA use was associated ...

No deaths occurred during the study. Solbinsiran is an N-acetylgalactosamine-conjugated small interfering RNA that targets hepatic expression of ANGPTL3, a key regulator of triglyceride and ...

Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting ...

The ALPACA trial showed that among patients with elevated lipoprotein(a), lepodisiran reduces mean serum concentrations of lipoprotein(a) from 60 to 180 days after administration. Participants were ...

Ways to gain weight with a fast metabolism include increasing caloric intake, eating more often, choosing healthy fats, and more. Metabolism is the rate at which you expend energy and use calories. A ...

Within the core program, TFE3 fusions directly regulate genes involved in ferroptosis resistance and oxidative phosphorylation metabolism (OxPhos). Consequently, human tRCC tumors display high OxPhos ...