Because of these effects, understanding the out-of-pocket costs for SGLT-2 inhibitors is essential. However, estimates for out-of-pocket costs are limited with no nationally representative or ...

This study identifies the deubiquitinating enzyme OTUB2 as a novel regulator of the RIPK1-RIPK3-MLKL necroptotic signaling and provides ... Consistently, inhibition of OTUB2 with the small-molecule ...

This month's cover highlights the article Boosting human immunology: Harnessing the potential of immune organoids by Dirk Baumjohann and Maximilian Moll. The review article explores recent advances in ...

Collectively, covalent inhibitors function based on their binding to MLKL and thereby inhibition on MLKL oligomerization and membrane translocation but not phosphorylation. However, the efficacy of ...

As per their name, entry/attachment inhibitors work by blocking the virus's ability to attach to or enter healthy host cells. They do so by binding to different receptors on the surface of the host ...

Panelists discuss exciting updates on Bruton tyrosine kinase (BTK) inhibitors from the 2024 American Society of Hematology (ASH) Annual Meeting and Exposition, highlighting emerging data that may ...

Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States ...

The above findings suggest that potent and selective inhibitors of RIPK1 would block RIPK1-dependent pro-inflammatory signaling, including the subsequent activation of RIPK3 and the downstream MLKL ...