ISS-based lab-on-a-chip model advances the understanding of muscle aging and degeneration in microgravity, guiding future therapeutic strategies.

While the study focused on A. thaliana, a model plant, ... Loss of myosin XI disrupts AtNIP5;1 positioning, impairs endocytic trafficking, and reduces boron absorption, ...

While the study focused on A. thaliana, a model plant, similar mechanisms could exist in crops like rice, wheat, and maize. Future research could explore whether enhancing myosin XI function or ...

An artificial intelligence safety firm has found that OpenAI's o3 and o4-mini models sometimes refuse to shut down, and will sabotage computer scripts in order to keep working on tasks.

The research, which has direct implications for how root systems manage responses to plant hormones, also has broader implications for understanding the condensation of other motile proteins that move ...

Figure 1.Single-molecule measurements of myosin dynamics using an optical tweezer system. (A–D) were modified from Hwang et al. (2021). (A) An actin-bead complex was interacted with a single myosin ...

Myosin VI is a unique reverse-directed motor protein in the myosin family. The D179Y mutation in Myosin VI is associated with deafness in mammals. This mutation destroys the processive motion of ...

According to the canonical model, nuclear import of soluble proteins is based on nuclear localization signals and transport factors. We challenge this view by showing that nuclear localization of the ...

eLife Assessment. The authors present a useful agent-based model to study the tensile force generated by myosin mini-filaments in actin systems (bundles and networks); by numerically solving a ...

Previous data supporting a model where myosin autoinhibition can be influenced by actin (Rohde et al, 2018) indicates that this may not always be true. Furthermore, the LSAR assay must be performed at ...

Our results indicated that myosin phosphatase target subunit 2 may be a potential target for preventing cardiac fibrosis and dysfunction in a model of mineralocorticoid receptor‐associated ...