The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out 49ers HC Kyle Shanahan for mishandling late-game situations. Colin Cowherd discusses this criticism and if it’s the biggest issue the 49ers have right now.

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an injury to his throwing shoulder.

San Francisco 49ers star linebacker Fred Warner revealed that he has been playing through a broken bone in his ankle since September.

One NFL team executive believes the San Francisco 49ers' 5-6 record is partially a product of Kyle Shanahan's coaching. "It's a combination of injuries

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's hard not to expect the best from Allen and the Bills this week. Beating the Chiefs the way they did helped them check off that confidence box, and they did it on their 12th straight week of football.

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game

Fred Warner, the backbone of the San Francisco 49ers' defense, admitted he's been playing through a fractured ankle, raising questions about the team’s handling of injuries.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live coverage begins at 7 PM ET on NBC and Peacock.

After the Green Bay Packers moved to 8-3, things are looking rosy as far as playoff qualification goes. Here's what to know.