In the PNS, one Schwann cell forms a single myelin sheath (Figure 1A). By contrast, in the CNS, the oligodendrocyte sends cell processes to myelinate multiple segments on many axons (Figure 2).

The axon is surrounded by multilamellar structure of myelin. (E) Myelinated nerve fiber reproduced in vitro by coculture of rat dorsal root ganglion neurons and Schwann cells. Myelin segments are ...

The Feltri lab research focused on adhesion between myelinating cells, axons and the extracellular matrix and the signals that promote myelination. One of their major efforts was the study of laminin ...