Get Instant Summarized Text (Gist) A specific form of the tau protein, the 1N4R isoform, has been identified as a key factor in mediating the toxic effects of protein clumps in Alzheimer's disease ...

A growing number of family members now provide care for older adults who live at home or in residential care settings, a new study shows. Their ranks increased 32%, from 18.2 million to 24.1 ...

The Canadian Creutzfeldt-Jakob Disease Surveillance System (CJDSS) is operated by the Public Health Agency of Canada and conducts prospective national surveillance for all types of human prion disease ...

Additionally, between 10% and 15% of cases of CJD are caused by a mutation in a gene called PRNP, which leads to the development of prions. This genetic form of CJD is inherited in an autosomal ...

We defined SERBP1’s interactome, uncovered novel roles in splicing, cell division and ribosomal biogenesis, and showed its participation in pathological stress granules and Tau aggregates in Alzheimer ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window A biomarker test identified tau pathology in Alzheimer's disease before fibrillary tangles developed. Neurofibrillary ...

The National Prion Disease Pathology Surveillance Center (NPDPSC) is the only Center of its kind in the U.S., which coordinates autopsies and neuropathologic examinations of suspected prion disease ...

Prion diseases comprise several conditions. A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. Prion diseases can affect both humans and animals. They are ...

Many neurodegenerative diseases are characterized by cellular deposits such as Abeta, Tau, alpha-synuclein, and huntingtin. The ability to image alpha-synuclein deposits in the human brain is ...

Prion Disease is currently an invariably fatal condition without treatment or cure. Despite multiple prior treatment studies, including quinacrine, doxycycline, and pentosan polysulfate, no ...

This seminar series brings together researchers from around the globe who study neurodegenerative diseases and age-related neurodegeneration using flies. The fruit fly Drosophila is an incredibly ...