When proteins are made in a cell, they start out as strings of amino acids, which have to be folded into the correct, 3D ...

Misfolded, prion-like proteins drive the progression of tauopathies (resulting in neurodegenerative diseases) characterized by the abnormal accumulation of misfolded tau protein in the brain.

The first synthetic fragment of tau protein has been created, revealing more about the diagnosis and treatment of neurodegenerative diseases. Researchers at Northwestern University (IL, USA) and the ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks ...

The study, "Water-directed pinning is key to tau prion formation," was supported by the National Institutes of Health (grant numbers R01AG05605 and R35GM136411), Deutsche Forschungsgemeinschaft ...

Prions transmit their abnormally folded shape onto other proteins. Researchers designed a synthetic fragment of the tau protein that exhibits prion-like behavior.

Prions transmit their abnormally folded shape onto other proteins. Researchers designed a synthetic fragment of the tau protein that exhibits prion-like behavior. Misfolded tau proteins are the ...

A new study from researchers at UC San Francisco (UCSF) has now shown that the tau tangles and plaques in DS are driven by the same amyloid beta (Aß) and tau prions that are implicated in AD.

published in the journal Nature, Kosik and his team have uncovered one such mechanism by which tau travels from neuron to neuron. Not only does it shed light on the extensively studied but rather ...