Tau pre-formed fibrils (PFFs) are commonly employed to simulate the prion-like spread of tau pathology in Alzheimer's disease (AD) and other tauopathies. Human induced pluripotent stem cell ...

Tau pathology continues to be a major focus in neurodegenerative disease research. Standard 2D models often miss the complex interactions between human neural cells and the spread of pathological tau ...

When proteins are made in a cell, they start out as strings of amino acids, which have to be folded into the correct, three-dimensional shape so they will function properly. Misfolded proteins can ...

The brain of a rat in which a fluorescent protein has been used to highlight transplanted human brain cells - Copyright Stanford University/AFP Sergiu PASCA The brain ...

Alzheimer's disease and other neurodegenerative conditions can sometimes feature damaging clumps of tau proteins that have become deformed. Scientists have now synthesized these misshapen entities in ...

The first synthetic fragment of tau protein has been created, revealing more about the diagnosis and treatment of neurodegenerative diseases. Researchers at Northwestern University (IL, USA) and the ...

Prions transmit their abnormally folded shape onto other proteins. Researchers designed a synthetic fragment of the tau protein that exhibits prion-like behavior. Misfolded tau proteins are the ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks ...