In this case, no PBP2x was detected, presumably due to degradation by proteases present in the commercial mutanolysin ... Also, we found that thiol reducing agents such as DTT routinely included when ...

Now, a new study from Scripps Research demonstrates a proof of concept for a new strategy: engineering proteases—enzymes that cut proteins at specific sites—to selectively degrade these ...

Erdosteine is a prodrug and metabolite I is the active metabolite of erdosteine owing to its free thiol group. In acute infective exacerbation of chronic bronchitis or chronic obstructive ...

Insulin is a hormone made in your pancreas, a gland located behind the stomach. It allows your body to use glucose for energy. Glucose is a type of sugar found in many carbohydrates. The body ...

Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering Imperial College London, London SW7 2AZ, U.K. Department of Physiology, Anatomy and Genetics, Department of ...

School of Materials and Energy & Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 611731, P. R. China College of Chemistry, State Key ...

7 Recent studies showed that sputum neutrophils in patients with bronchiectasis correlated with worse pulmonary function, bacterial colonisation, and disease severity due to excess proteases ...

These proteases are ubiquitously represented across all domains of life and serve diverse functions including protein maturation, activation of signaling molecules and protein degradation. Categorized ...

“The screen checks the activity of the inhibitor in a real cell environment which includes proteases and other proteins that can sometimes interfere with peptide activity, whilst also checking ...