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In Dscamb mutants, however, red cone filopodia failed to properly retract after contact with the same red cone-type and instead remained attached or even invaded the apical surface of neighboring ...

Objective—Platelet adhesion to subendothelial collagen is dependent on the integrin α2β1 and glycoprotein VI (GPVI) receptors. The major signaling routes in collagen-dependent platelet activation are ...

One type of higher-order assembly is the hexagonal bundle found within filopodia. A protein called fascin binds and bridges pairs of actin filaments, stitching them into bundles.

Credit: Alushin Lab One type of higher-order assembly is the hexagonal bundle found within filopodia. A protein called fascin binds and bridges pairs of actin filaments, stitching them into bundles.

While the ability of phagocytes to actively deploy filopodia has been demonstrated, relatively little is known about the specific intracellular molecules and receptor-types that participate in ...

They also found that filopodia had only one of the two types of receptors found in a typical active synapse, both of which bind the neurotransmitter glutamate.

A recent MIT study shows that millions of silent synapses exist in adult brains—a discovery that may unlock how adults are able to continually learn and form new memories.

The next thing to investigate is how, why and when new filopodia appear. The discovery of all these eager-to-learn silent synapses and filopodia, Dr Harnett says, “is a lever for us to get into ...

Nature research paper: Filopodia are a structural substrate for silent synapses in adult neocortex. AlphaFill: enriching AlphaFold models with ligands and cofactors - Nature Methods.

Filopodia are a structural substrate for silent synapses in adult neocortex. Nature. Published online November 30, 2022:1-5. doi: 10.1038/s41586-022-05483-6 This article has been republished from the ...