The Hoosiers jumped out to an early lead when quarterback Kurtis Rouke handed the ball off to Ty Son Lawton, who scored the game's first touchdown. However, this lead was short-lived, as the Buckeyes' defense quickly took control.

No. 2 Ohio State stifled No. 5 Indiana, winning 38-15 to inch closer to a Big Ten title bid while handing the Hoosiers their first loss.