IFITM3 protein found to play critical role in restricting viral replication in vivo. People who carry a particular variant of the interferon-inducible transmembrane 3 (IFITM3) gene are more likely ...

IFITM3 deficiency is not rare: About 20% of Chinese people and 4% of people of European ancestry have genetic mutations that disable the immune system's production of the protein.

IFITM3 (pronounced I-fit-M-3, for interferon-induced transmembrane protein 3) is key to the innate immune system’s clearance of viruses. It is produced in large quantities after flu is present and ...

Using the IFITM3 tools and assays they'd developed for studying dengue and influenza viruses, the Brass lab was able to rapidly test IFITM3's effect on Zika virus.

How key protein protects against viral infections Date: April 2, 2012 Source: University of Utah Health Sciences Summary: Scientists have discovered that a mouse protein called IFITM3 contributes ...

This, he says, is where IFITM3 plays a crucial role. “This protein prevents the virus from ever leaving the 'compartment,'” he tells mental_floss.

Consistent with their previous findings in the study, the IFITM3-rel had similar levels of E-protein positive cells as the control cell line; however, the IFITM3-high levels had a significant ...

Levels of IFITM3 are known to increase with age, and higher than average IFITM3 levels have been seen in some patients suffering late-onset Alzheimer’s disease.

IFITM3 blocks Zika virus infection. When human cells are exposed to Zika virus they are overwhelmingly infected, as seen by the large number of green cells (left panel).

They will also explore IFITM3 as a biomarker for the disease and as a potential target for new drugs designed to treat it. ### Journal. Nature. DOI. 10.1038/s41586-020-2681-2 .