There is, if you squint, the faintest of links to Arcane with one of them at least: Noxus is the home region of the show's Mel and Ambessa Medarda. Other than that, the three regions mentioned by Linke are among the oldest and most lore-packed in LoL's mythology, with plenty of champions to choose from, so they could go anywhere.

Riot Games co-founder Marc Merrill explained why Arcane didn’t get a Season 3 and revealed his ambitions with League of Legends.

In an interview with League content creator Necrit, Riot creative director and Arcane creator and showrunner Christian Linke revealed the three Runeterra regions it's exploring as settings for future shows: Noxus, Ionia, and Demacia.