eLife

Mouse models with human antibody repertoires for inducing multiple lineages of HIV-1 broadly neutralizing antibodies

This important study advances the HIV-1 vaccine development field by establishing six humanized immunoglobulin knock-in mouse models to facilitate the design and evaluation of HIV-1 vaccines. The ...
eLife

Neuropeptides NLP-10 and FLP-18 stimulate lipid catabolism in chronically diet-restricted Caenorhabditis elegans

Neuropeptides mediate inter-tissue communication in energy metabolism, yet most remain functionally uncharacterized. Using C. elegans, we uncover a neuropeptide signaling cascade that drives lipid ...
eLife

Dual reinforcement-learning network modules for modeling decision-making with multiple strategies

Laboratory of Neural Computation, Institute for Quantitative Biosciences, the University of Tokyo, Tokyo, Japan Department of Life Sciences, Graduate School of Arts and Sciences, the University of ...
eLife

Global Nernstian astrocytic depolarization breaks down during local synaptic input

The authors use a modeling approach to examine the effects of local and global perturbations on the electrophysiological properties of astrocytes: their modeling results suggest that local ionic ...
eLife

Female acoustic signaling of sexual immaturity depresses male courtship in Drosophila

This important study characterizes wing flicking in sexually immature Drosophila melanogaster females as a rejection response behavior that produces patterned acoustic signals and suppresses male ...
eLife

Number, order and time influence how the brain integrates distinct experiences

chaining is more likely when the experiences to be integrated are relatively familiar (greater number of exposures) and ordered in a manner that promotes encoding of the associative links that are ...
eLife

Correlative light–electron microscopy reveals fundamentally different axonal architectures for fast and modulatory transmission

We used correlative light and focussed ion beam–scanning electron microscopy (FIBSEM) to characterise the ultrastructural organisation of neuromodulatory axons in the upper layers of the adult mouse ...
eLife

Dawn of segmented bilaterians unveiled by soft-bodied fossils in microbial pseudomorphs from the Basal Cambrian

This important manuscript reports exceptionally preserved, millimeter-scale segmented bilaterian microfossils from the early Cambrian Fortunian Kuanchuanpu Formation in South China. The authors ...
eLife

Mechanosensory Physiology: Lymphatic vessels under pressure

Lymphatic vessels beat faster as they fill with fluid through a chain of calcium signaling, though the first pressure sensor ...
eLife

The psychedelic DOI decreases the modularity of the cortical network by increasing cortico-cortical and thalamo-cortical functional influence

This important study combines cortex-wide activity imaging and optogenetics to characterize large-scale changes in functional connectivity following administration of the psychedelic DOI, as well as ...
eLife

Revealing the benefit of eye motion for acuity under emulated cone loss

In the presence of emulated cone loss, eye movements are used to gather and integrate information, leading to improved letter ...
eLife

Glutamate receptor composition at Drosophila neuromuscular junctions depends on developmental stage and muscle identity

Diverse combinations of glutamate receptor subunits are expressed across developmental stages and even between adjacent ...