eLife

Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development

Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on ...
eLife

Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

This valuable study presents an analysis of the gene regulatory networks that contribute to tumour heterogeneity and tumor plasticity in Ewing sarcoma, with key implications for other fusion-driven ...
eLife

Trained immunity and immune priming in plants and invertebrates

An evolutionary perspective on immune priming across plants and invertebrates highlights the roles of microbiomes and epigenetic regulation in shaping innate immune memory with promising applications ...
eLife

Microsaccades track shifting but not necessarily maintaining covert visual-spatial attention

This useful study demonstrates that microsaccade direction primarily indexes shifts rather than the maintenance of covert spatial attention, offering a focused interpretation that may help reconcile ...
eLife

Evolutionary remodeling of non-canonical ORF translation in mammals

This study presents a large, systematically curated catalog of non-canonical open reading frames (ncORFs) in human and mouse by reanalyzing nearly 400 Ribo-seq datasets using a standardized pipeline; ...
eLife

Individual differences in tail risk sensitive exploration using Bayes-adaptive Markov decision processes

A normative computational model of individual differences in mouse exploration driven by reward and threat uncertainty as well as risk sensitivity when faced with a novel object in an open field.
eLife

eLife Latest: Promoting equity, diversity and inclusion – December 2025 update

We highlight recent developments in eLife’s equity, diversity and inclusion framework and what steps we plan to take next ...
eLife

Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis

Step selection functions are a useful tool for analysing fine-scale human movements to understand environmental interactions in the context of infectious disease epidemiology.
eLife

Neuronal Activity: Keeping track of moving targets

A new method for tracking the activity of individual neurons day after day in the growing brain has revealed a key developmental transition in neuronal activity.
eLife

Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

This manuscript makes a valuable contribution to the concept of fragility of meta-analyses via the so-called 'ellipse of insignificance for meta-analyses' (EOIMETA). The strength of evidence is solid, ...
eLife

Bivalent mRNA booster encoding virus-like particles elicits potent polyclass RBD antibodies in pre-vaccinated mice

This report provides useful evidence that EABR mRNA is at least as effective as standard S mRNA vaccines for the SARS-CoV-2 booster vaccine. Although the methodology and the experimental approaches ...
eLife

Geomagnetic and visual cues guide seasonal migratory orientation in the nocturnal fall armyworm, the world’s most invasive insect

This fundamental study presents experimental evidence on how geomagnetic and visual cues are integrated in a nocturnally migrating insect. The evidence supporting the conclusions is compelling. The ...