Introduction and Objectives Approximately 1 in every 4100 people worldwide are born with oesophageal atresia ± tracheo-oesophageal fistula (OA/TOF). Whilst surgical correction is, in most cases, ...

Background: Oxidative stress is thought to have a major role in the pathogenesis of airway obstruction. A study was undertaken to determine whether subjects with low levels of antioxidants (serum ...

Background: Malignant pleural effusion (MPE) is a common clinical problem with described investigation pathways. While thoracic ultrasound (TUS) has been shown to be accurate in pleural fluid ...

Background All lung cancer CT screening trials used fixed follow-up intervals, which may not be optimal. We developed new lung cancer risk models for personalising screening intervals to 1 year or 2 ...

Background Alveolar macrophages (AM) in COPD have fundamentally impaired responsiveness to Toll-like receptor 2 (TLR2) and TLR4 ligands of non-typeable Haemophilus influenzae (NTHI). However, the ...

Background Debate about the optimal lung cancer screening strategy is ongoing. In this study, previous screening history of the Dutch-Belgian Lung Cancer Screening trial (NELSON) is investigated on if ...

Background and objectives IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder originally described in association with autoimmune pancreatitis (AIP), usually but not always in ...

Introduction We delivered a one-year weight management programme (Counterweight Plus, CWP) in participants with difficult-to-treat asthma and obesity in a single-centre randomised controlled trial ...

Introduction Despite improvements in pulmonary function, physical activity (PA) levels remain significantly lower than the general population, even at 1 year following lung transplantation (LTx).

Background This study reports preliminary outcomes from a joint Respiratory Consultant and Speech and Language Therapist (SLT) ‘one stop’ cough clinic. Local and tertiary referrals were accepted.

Rationale Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and cardiovascular disease. Interaction between inflammatory cells and activated platelets is important ...

Objective Long-term azithromycin treatment effectively prevents acute exacerbations of chronic obstructive pulmonary disease ...