cGAS STING in stroke and ischemic injury. The cGAS pathway is activated during Ischemic stroke, which is a debilitating neurological disorder causing elevated neuroinflammation. The …

Jan 18, 2023 · DNA-damage-induced cGAMP synthase (cGAS)-stimulator of interferon genes (STINGs) activation is the functional downstream signaling. Directly activating neuronal STING …

Jul 1, 2023 · cGAS-STING pathway has pro- and anti-nociceptive effects in pain models. cGAS-STING pathway functions vary in neuron and immune cells. Downstream molecules of cGAS …

In this narrative review, we summarize the recent findings on the involvement of the cGAS-STING pathway in chronic pain, as well as several possible mechanisms underlying its activation.

Recent studies have demonstrated that cGAS-STING signaling is strongly implicated in the pathogenesis of central nervous system (CNS) diseases which are underscored by …

Oct 10, 2023 · Our findings revealed for the first time that spinal TAOK2 is expressed in afferent nerve endings and contributes to neuropathic pain via activation of cGAS-STING signaling, …

Nov 11, 2022 · DNA-damage-induced cGAMP synthase (cGAS)-stimulator of interferon genes (STINGs) activation is the functional downstream signaling. Directly activating neuronal STING …

Mar 25, 2019 · At the intersection of neurobiology and immunology, neuroinflammation presents an exciting application of the cGAS-STING pathway for neuroscientists and neurologists. …

Oct 1, 2022 · Spared nerve injury (SNI) surgery was conducted in adult male rats to establish a neuropathic pain model. We showed that SNI promoted microglial M1-polarization and …

Oct 4, 2022 · We ultimately aim to provide a more in-depth understanding of the mechanism through which STING signalling modulates the nerve inflammatory response in CNS injury and …