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Columns specified in USP monographs are usually designated by an L classification; L1 refers to columns bonded with a C18 functional group. Can you expect equivalent retention and selectivity from columns with the same L designation? Let's find out in #TrustYourScience episode 2! | Waters Corporation
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Retaining polar acidic compounds under reversed-phase conditions on a traditional C18 column is challenging. The hydrophobic surface is not a friendly environment for polar analytes, and the ionize silanols produce a negative charge repel polar acids. In this episode of "Trust Your Science", Jonathan and Kim discuss and investigate a stationary phase designed to retain polar acids under reversed phase conditions. #trustyourscience Learn more https://bit.ly/2RRyUNh | Waters Corporation
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